Dutasteride / tamsulosin (Jalyn and others)

How Medicare covers it

Part D (forms used at home). Part A during a covered inpatient stay. No Part B clinician-administered form in the CMS Part B spending file.

What it treats

This combination capsule (brand name Jalyn) treats the symptoms of benign prostatic hyperplasia (BPH), which is an enlarged prostate, in men who have an enlarged prostate. It is not approved to prevent prostate cancer.

What it is for, in depth

This medicine is for men with symptomatic benign prostatic hyperplasia (BPH) who have an enlarged prostate. BPH symptoms include trouble starting urination, a weak stream, and needing to urinate often. The combination fits men who need both actions at once: tamsulosin relaxes the prostate and bladder neck so urine flows more easily, while dutasteride slowly shrinks the prostate itself by blocking DHT production. The label is clear that dutasteride products, including this combination, are not approved for the prevention of prostate cancer. Form and strength: one hard-shell capsule containing 0.5 mg dutasteride and 0.4 mg tamsulosin hydrochloride, taken once daily. Bottles of 30 and 90 are listed in the label.

How it works

It combines two drugs that work in different ways. Dutasteride is a 5-alpha-reductase inhibitor: it blocks the enzyme that changes testosterone into DHT, the hormone mainly responsible for prostate growth, so it helps shrink the prostate over time. Tamsulosin is an alpha blocker: it relaxes the smooth muscle in the prostate and bladder neck, which improves urine flow and eases BPH symptoms.

How it is taken

Take 1 capsule once a day, about 30 minutes after the same meal each day. Each capsule has 0.5 mg of dutasteride and 0.4 mg of tamsulosin hydrochloride. Swallow the capsule whole — do not chew it or open it, because contact with the contents can irritate the mouth and throat.

Common side effects

The most common side effects, reported in 1% or more of people treated with dutasteride and tamsulosin together, are ejaculation disorders, impotence, decreased sex drive (libido), dizziness, and breast disorders.

Serious warnings

This drug can cause low blood pressure when you stand up (orthostatic hypotension) and fainting, so be careful in situations where fainting could cause injury. It lowers the PSA blood test level by about 50%, so any confirmed rise in PSA while taking it should be checked for prostate cancer even if the number still looks normal. Dutasteride products may raise the risk of high-grade prostate cancer. A rare but serious prolonged erection (priapism) can happen. During cataract or glaucoma surgery, a problem called Intraoperative Floppy Iris Syndrome has been seen in people who take or have taken alpha blockers, so tell your eye surgeon you take this drug. Do not donate blood until 6 months after your last dose.

Who should be careful

It must not be used in pregnancy, and women who are pregnant or may become pregnant should not handle the capsules, because dutasteride can harm a developing male fetus. It must not be used by anyone who has had a serious allergic reaction to dutasteride, other 5-alpha-reductase inhibitors, tamsulosin, or any ingredient. Before starting, your doctor should consider other urinary conditions that can cause the same symptoms. People planning cataract or glaucoma surgery should tell their eye doctor about this medicine.

Major interactions

Do not use it with other alpha blockers, because that raises the risk of low blood pressure. Do not use it with strong CYP3A4 inhibitors such as ketoconazole. Use caution with moderate CYP3A4 inhibitors such as erythromycin, with strong or moderate CYP2D6 inhibitors such as paroxetine, with combinations of these inhibitors, and if you are a known poor metabolizer of CYP2D6 — these can greatly raise drug levels. Use caution with PDE-5 inhibitors (erection medicines), which can also increase low blood pressure risk, and with warfarin.

Cost and saving notes

Costs vary by plan. If your plan places this drug on a high tier or does not cover it, you can ask the plan for a tier exception or a coverage review. People with low income may qualify for Extra Help, the Medicare program that helps pay Part D drug costs. Ask your plan what your exact cost will be before you fill it.

Why it is in its tier

Dutasteride / tamsulosin (Jalyn and others) sits on Tier 4 in 52.86% of the plans that list it (1923 of 3638 listing plans). Tier 4 is the non-preferred tier — higher copays or coinsurance. The data-visible drivers: It is a generic product, and the CMS dashboard puts its average Part D spending at about $702 per beneficiary for 2024 — a relatively low-cost drug, which matches where plans place it. It is listed by 66.21% of Part D plans. The tier shown is the most common one; individual plans vary.

Sources

• JALYN (DUTASTERIDE AND TAMSULOSIN HYDROCHLORIDE) CAPSULE [WAYLIS THERAPEUTICS] — DailyMed

Part D formulary coverage

Source: CMS Prescription Drug Plan Formulary, Pharmacy Network, and Pricing Information Files — Monthly file 2026-10-15 (plan year 2027), file 2027_20261008.zip (data.cms.gov dataset ed1496ea-23e7-41f1-9292-172fa842ccfb): basic drugs formulary file + plan information file, both dated 20261031 inside the zip; downloaded and aggregated 2026-10-30. Medication RxCUI sets resolved through the NLM RxNav (RxNorm) API.

What you pay

Without insurance, the cash benchmark is 1.86428 per unit (DUTASTERIDE-TAMSULOSIN 0.5-0.4) — about nan for 30 units. NADAC benchmark — the average price pharmacies pay (CMS, as of 2026-11-04). Pharmacy shelf prices vary.

A tier is not a price; what you pay depends on your plan, pharmacy, and benefit stage; Extra Help or Medicaid can lower it further.

Sources: CMS Plan Benefit Package + formulary data; CMS NADAC · Checked 2026-11-07

Coverage by plan and tier

Of the 5,495 Medicare drug plans we track for 2027, 3,638 list Dutasteride / tamsulosin (Jalyn and others) — 66.2% of plans. Most of those plans put it on Tier 4: 1,923 plans, 52.9% of the plans that list it. Other plans place it on Tier 3 (1,161 plans), Tier 2 (279 plans) or Tier 1 (275 plans). For example: Aetna Medicare Dual Extra (HMO D-SNP) puts it on Tier 4; Aetna Medicare Dual Extra Care (PPO D-SNP) puts it on Tier 4; Aetna Medicare Value Plus (PPO) puts it on Tier 4. You can compare these plans side by side on our Medicare Advantage hub. A tier is not a price. What you pay also depends on whether you have met your plan';s deductible, whether the drug costs a flat copay or a share of the price, and whether you get Extra Help or Medicaid.

Read next

• Part D in 2027: The $700 Deductible, the $2,400 Cap, and the $35 Insulin Rule
• Extra Help in 2027: Lower Drug Copays and Who Qualifies
• Checking Medicare Savings Programs and Extra Help

Part D spending averages (2024)

Source: CMS Medicare Part D Spending by Drug (Drug Spending Dashboard), release RY26 P04 V10, data through 2024 (DSD_PTD_RY26_P04_V10_DY24_BGM.csv), downloaded 2026-10-30

Companies covering this drug

Part D and Medicare Advantage plan sponsors that list this drug on a formulary, 50 at a time.