Nystatin / triamcinolone (Mycolog II and others)

How Medicare covers it

Part D (cream and ointment used at home). Part A during a covered inpatient stay. No Part B clinician-administered form in the CMS Part B spending file.

What it treats

The pinned label extract for this slug does not contain a usable nystatin-triamcinolone label, so no labeled use for nystatin-triamcinolone can be stated from it. The extract's title is for a different product (see label_title below), and its only indications text is for that other product. As package-record context only — not from the label extract — the package record describes nystatin / triamcinolone as: 'A combination skin cream/ointment: nystatin kills the fungus and triamcinolone (a steroid) calms inflammation — used for inflamed fungal skin infections such as candidiasis.' That record wording is flagged here as package-record context, and it is not presented as the FDA-approved indication from the pinned extract.

What it is for, in depth

This entry has a label problem that readers need to know about plainly: the pinned label extract is titled 'MYCOLOGICAL IMMUNE STIMULATOR 6010 (MYCOLOGICAL IMMUNE STIMULATOR) LIQUID [PROFESSIONAL COMPLEMENTARY HEALTH FORMULAS]' — a different product, with only tiny indications and dosage sections about temporary relief of runny nose, sneezing, itching of the nose or throat, itchy or watery eyes, cough, shortness of breath, occasional headache, red or itchy skin, irritability, or fatigue, and drops under the tongue. None of that text is about nystatin-triamcinolone and none of it is used in this entry as if it were. The pinned extract contains no usable nystatin-triamcinolone label sections: no indications, description, clinical pharmacology, warnings, adverse reactions, interactions, populations, contraindications, or how-supplied information for the combination. What can be said from the package record — flagged here as package-record context, not label text — is that the record describes a combination skin cream/ointment used for inflamed fungal skin infections such as candidiasis, and the record matches two forms in the CMS formulary file: nystatin 100 UNT/MG / triamcinolone acetonide 0.001 MG/MG topical ointment and nystatin 100000 UNT/ML / triamcinolone acetonide 1 MG/ML topical cream. No dosing, side effects, warnings, or interactions for the combination are given in this entry, because the pinned extract does not support them.

How it works

The pinned label extract gives no information about how nystatin, triamcinolone, or their combination works. It has no description, clinical pharmacology, or mechanism section for nystatin-triamcinolone. No mechanism is stated here, because none can be traced to this extract, and the other product named in the extract must not be used to fill this field.

How it is taken

The pinned label extract gives no dosing, form, or directions for nystatin-triamcinolone cream or ointment. The only dosage text in the extract — drops placed under the tongue — belongs to the different product named in the extract's title and must NOT be used as directions for nystatin-triamcinolone. Anyone prescribed nystatin-triamcinolone should follow the directions on their own product and their prescriber's instructions, not this pinned extract.

Common side effects

The pinned label extract has no adverse reactions section for nystatin-triamcinolone and lists no side effects for this combination. No side effects are stated here, because none can be traced to this extract and inventing a list from memory would be unsafe.

Serious warnings

This label has no boxed warning, but the main problem with the pinned extract is that it is not a nystatin-triamcinolone label at all. It contains no warnings, contraindications, or precautions section for nystatin-triamcinolone, so no label warnings for this combination can be quoted or summarized from it. Do not rely on this extract for safety information about nystatin-triamcinolone; use the label that comes with the actual prescribed product and ask the prescriber or pharmacist about warnings.

Who should be careful

The pinned label extract gives no contraindications, populations, or caution information for nystatin-triamcinolone, so no group can be named from this extract as one that must avoid it or be careful with it. Because the extract is for a different product, anyone using nystatin-triamcinolone — especially on broken or infected skin, for a long time, or in children — should check the actual product label and their prescriber rather than relying on this page's pinned extract.

Major interactions

The pinned label extract has no drug interactions section for nystatin-triamcinolone and names no interacting drugs for this combination. No interactions are stated here, because none can be traced to this extract.

Cost and saving notes

Medicare facts: the package record lists this drug as 'Nystatin / triamcinolone (Mycolog II and others)' and matches generic combination forms in the CMS formulary file. In the package record's 2027 CMS formulary file, the most common (modal) tier was tier 4. If your own Part D plan places it on a higher tier than expected, you or your prescriber can ask the plan for a tier exception when the lower-tier options would not work as well for you. If you qualify for Extra Help (the Part D Low-Income Subsidy), your premiums and copays drop a lot. In 2027, what you pay out of pocket for covered Part D drugs is capped at $2,400 for the year, and the Medicare Prescription Payment Plan lets you spread those costs into monthly payments instead of paying large amounts at the pharmacy counter. Ask your pharmacist or your plan what you would actually pay before you fill.

Why it is in its tier

Nystatin / triamcinolone (Mycolog II and others) sits on Tier 4 in 59.39% of the plans that list it (1594 of 2684 listing plans). Tier 4 is the non-preferred tier — higher copays or coinsurance. The data-visible drivers: It is a generic product, and the CMS dashboard puts its average Part D spending at about $44.96 per beneficiary for 2024 — a relatively low-cost drug, which matches where plans place it. Only 48.84% of Part D plans list it at all, so many readers will find their plan does not list it and covers a similar drug instead. The tier shown is the most common one; individual plans vary.

Sources

• MYCOLOGICAL IMMUNE STIMULATOR 6010 (MYCOLOGICAL IMMUNE STIMULATOR) LIQUID [PROFESSIONAL COMPLEMENTARY HEALTH FORMULAS] — DailyMed
• MedlinePlus — Nystatin and Triamcinolone

What official patient guides say

The combination of nystatin and triamcinolone comes as an ointment and as a cream to be applied to the skin. It is usually applied twice a day for no longer than 2 weeks. Use it exactly as directed — do not use more, less, or use it more often than prescribed by your doctor. Wash the affected area thoroughly, then apply a small amount of cream or ointment and gently and thoroughly massage it into your skin. If you use this medication on your face, keep it out of your eyes. If you are using it on a child's diaper area, do not place tightly fitting diapers or plastic pants on the child, because they can increase absorption of the triamcinolone, which can affect the child's growth. If you miss a dose, apply it as soon as you remember. If it is almost time for the next dose, skip the missed dose and go back to your regular schedule. Do not apply a double dose. Keep it in the container it came in, tightly closed and out of reach of children. Store it at room temperature, away from extra heat and moisture, and not in the bathroom.

Source: MedlinePlus — Nystatin and Triamcinolone

Part D formulary coverage

Source: CMS Prescription Drug Plan Formulary, Pharmacy Network, and Pricing Information Files — Monthly file 2026-10-15 (plan year 2027), file 2027_20261008.zip (data.cms.gov dataset ed1496ea-23e7-41f1-9292-172fa842ccfb): basic drugs formulary file + plan information file, both dated 20261031 inside the zip; downloaded and aggregated 2026-10-30. Medication RxCUI sets resolved through the NLM RxNav (RxNorm) API.

What you pay

Without insurance, the cash benchmark is 0.22211 per unit (NYSTATIN-TRIAMCINOLONE CREAM) — about nan for 30 units. NADAC benchmark — the average price pharmacies pay (CMS, as of 2026-11-04). Pharmacy shelf prices vary.

A tier is not a price; what you pay depends on your plan, pharmacy, and benefit stage; Extra Help or Medicaid can lower it further.

Sources: CMS Plan Benefit Package + formulary data; CMS NADAC · Checked 2026-11-08

Coverage by plan and tier

Of the 5,495 Medicare drug plans we track for 2027, 2,684 list Nystatin / triamcinolone (Mycolog II and others) — 48.8% of plans. Most of those plans put it on Tier 4: 1,594 plans, 59.4% of the plans that list it. Other plans place it on Tier 2 (747 plans), Tier 1 (217 plans) or Tier 3 (126 plans). For example: CareSource MyCare Ohio (HMO D-SNP) puts it on Tier 1; Humana Total Complete (HMO) puts it on Tier 4; Humana Dual Integrated (HMO D-SNP) puts it on Tier 4. You can compare these plans side by side on our Medicare Advantage hub. A tier is not a price. What you pay also depends on whether you have met your plan';s deductible, whether the drug costs a flat copay or a share of the price, and whether you get Extra Help or Medicaid.

Read next

• Part D in 2027: The $700 Deductible, the $2,400 Cap, and the $35 Insulin Rule
• Extra Help in 2027: Lower Drug Copays and Who Qualifies
• Checking Medicare Savings Programs and Extra Help

Part D spending averages (2024)

Source: CMS Medicare Part D Spending by Drug (Drug Spending Dashboard), release RY26 P04 V10, data through 2024 (DSD_PTD_RY26_P04_V10_DY24_BGM.csv), downloaded 2026-10-30

Companies covering this drug

Part D and Medicare Advantage plan sponsors that list this drug on a formulary, 50 at a time.